Studies directed toward the exploitation of vicinal diols in the synthesis of (+)-nebivolol intermediates

• Runjun Devi and
• Sajal Kumar Das

Beilstein J. Org. Chem. 2017, 13, 571–578, doi:10.3762/bjoc.13.56

• opening; heterocycles; nebivolol; syn-epoxide; Findings Chiral chromans are prevalent components of a large number of natural products, natural product-like molecules and pharmaceutical drugs, possessing diverse biological activities [1]. In view of their wide spectrum of biological profiles, chiral

cis-Diastereoselective synthesis of chroman-fused tetralins as B-ring-modified analogues of brazilin

• Dimpee Gogoi,
• Runjun Devi,
• Pallab Pahari,
• Bipul Sarma and
• Sajal Kumar Das

Beilstein J. Org. Chem. 2016, 12, 2816–2822, doi:10.3762/bjoc.12.280

• been reductively removed by a diastereoselective method which should be useful in future for preparing libraries of chroman-fused tetralins with trans-stereochemistry at the ring junction. Keywords: brazilin; chroman; epoxy-arene cyclization; natural-product-like molecules; tetralin; Findings The

• chroman unit occurs widely as a privileged framework in a large number of natural products (NPs), natural product-like molecules (NPLMs) and pharmaceuticals, possessing diverse biological activities [1]. (+)-Brazilin (1) and (−)-haematoxylin (2) are two structurally-related tetracyclic homoisoflavonoid

• studied during the past 15 years [19]. Moreover, on many occasions natural product-like molecules exhibit more potent biological activities than the parent natural products [20]. Meanwhile, the intramolecular Friedel–Crafts epoxy–arene (IFCEA) cyclization has been well-established as a powerful tool for

Synthesis of skeletally diverse alkaloid-like molecules: exploitation of metathesis substrates assembled from triplets of building blocks

• Sushil K. Maurya,
• Mark Dow,
• Stuart Warriner and
• Adam Nelson

Beilstein J. Org. Chem. 2013, 9, 775–785, doi:10.3762/bjoc.9.88

• of building blocks used in this study. Panel A: fluorous-tagged initiating building blocks. Panel B: propagating building blocks. Panel C: terminating building blocks. Illustrative examples of a synthetic approach to natural-product-like molecules with over eighty molecular scaffolds. Overview of the